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trung binh 34kg/m2; tuoi trung binh 51 tuoi) dtfdc chia
lam 3 nhom.
Nhom 1: tich ctfc dieu chinh loi song bang che do an
va tap the due;
Nhom 2: dung thuoc metformin:
Nhom 3: dung gia dtfdc.
Sau thdi gian nghien ctfu trung binh 2.8 nam,
nhom tich ctfc dieu chinh loi song giam dtfdc tdi
58% nguy cd ttfdng doi tien trien thanh DTD. trong khi
nhom dung metformin giam dude 31% nguy cd. [Nhieu
tac gid, (2002), “Diabetes Prevention Research Group:
Reduction in the evidence of typ 2 diabetes with
lifestyle or metformin'', N Eng J Med 346:393-403.]
Nghien ciiu thi/3: tien hanh tren 235 phu ntf Tay
Ban Xha co tien stf mac DTD luc co thai dude chia
ngau nhien thanh 2 nhom.
Nhom 1: uong ti'oglitazone-thuoc true tiep lam
giam de khang insulin.
Nhom 2: dung gia du'Oc.
Sau thoi gian nghien ctfu trung binh 30 thang.
nhom dung troglitazone giam du'oc 56% nguy cd tien
trien thanh DTD. Dac biet. sau khi ngtfng thuoc hdn 8
* . ° —
thang. hieu luc phong ngtfa tien trien thanh DTD van
con co tac dung. [Buchanan TA, (2002), Preservation
of pancreatic beta cell function and prevetion of typ 2
diabetes by pharmacological treatment of insulin resistance
in high-risk Hispanic women. Diebetes 5, 2796-2803.]
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